反应详情

To a solution of ethyl 4-[(3-methoxypropyl)amino]-6-(1-methylethyl)pyridine-3-carboxylate (263 mg) in ethanol (5 ml) was added 2 M aqueous sodium hydroxide solution (0.94 ml) and the mixture was stirred at room temperature for 15 hr. The reaction mixture was adjusted to pH 7 with 1 M hydrochloric acid, and the solvent was evaporated under reduced pressure. The residue was suspended in ethanol, and the precipitated inorganic salt was filtered off. The filtrate was concentrated under reduced pressure to give the object compound (300 mg) as a mixture of inorganic salts.

1. customthe solvent was evaporated under reduced pressure
2. filtrationthe precipitated inorganic salt was filtered off
3. concentrationThe filtrate was concentrated under reduced pressure