反应详情

To a solution of t-butyl[4-(hydroxymethyl)-1,3-thiazol-2-yl]carbamate (1.21 g) in dichloromethane (15 mL) was added diethylaminosulfur trifluoride (0.73 mL) under cooling in a dry ice-acetone bath, followed by stirring for 30 minutes under cooling as it is in a dry ice acetone bath. To the reaction mixture was added saturated aqueous sodium bicarbonate, followed by extraction with ethyl acetate. The organic layer was washed with saturated brine, dried over anhydrous magnesium sulfate, and then concentrated to obtain t-butyl[4-(fluoromethyl)-1,3-thiazol-2-yl]carbamate (480 mg) as a white solid.

1. temperatureunder cooling in a dry ice-acetone bath
2. temperatureunder cooling as it
3. customis in a dry ice acetone bath
4. extractionfollowed by extraction with ethyl acetate
5. washThe organic layer was washed with saturated brine
6. dry with materialdried over anhydrous magnesium sulfate
7. concentrationconcentrated