反应详情

To a solution of tert-butyl {5-[2-(benzyloxy)ethoxy]pyrazin-2-yl}carbamate (614 mg) in dichloromethane (10 mL) was added trifluoroacetic acid (0.68 mL) at room temperature, followed by stirring at room temperature overnight. After concentration, saturated aqueous sodium bicarbonate was added thereto. After extraction with ethyl acetate, the organic layer was dried over anhydrous magnesium sulfate. The crude product obtained by concentration was purified by basic silica gel column chromatography (hexane:ethyl acetate=5:1-1:1) to obtain 5-[2-(benzyloxy)ethoxy]pyrazin-2-amine (269 mg) as a pale yellow solid.

1. concentrationAfter concentration, saturated aqueous sodium bicarbonate
2. additionwas added
3. extractionAfter extraction with ethyl acetate
4. dry with materialthe organic layer was dried over anhydrous magnesium sulfate
5. customThe crude product obtained by concentration
6. customwas purified by basic silica gel column chromatography (hexane:ethyl acetate=5:1-1:1)