反应详情

To a solution of N-[5-(1-hydroxyethyl)pyrazin-2-yl]-2,2-dimethylpropanamide (394 mg) in methanol (10 mL) was added potassium carbonate (249 mg) at room temperature, followed by stirring at room temperature overnight and stirring at 60° C. for 5 hours. Further, potassium carbonate (249 mg) was added thereto, followed by stirring at 60° C. for 3 hours. After leaving it to be cooled to room temperature, saturated brine was added to the reaction mixture, followed by extraction with a solvent (chloroform:isopropyl alcohol=4:1). The organic layer was dried over anhydrous magnesium sulfate and concentrated. The obtained solid was collected by filtration while washing with a solvent (hexane:diisopropyl ether=1:1), to obtain 1-(5-aminopyrazin-2-yl)ethanol (187 mg) as a pale yellow solid.

1. stirringstirring at 60° C. for 5 hours
2. stirringby stirring at 60° C. for 3 hours
3. customAfter leaving it
4. temperatureto be cooled to room temperature
5. extractionfollowed by extraction with a solvent (chloroform:isopropyl alcohol=4:1)
6. dry with materialThe organic layer was dried over anhydrous magnesium sulfate
7. concentrationconcentrated
8. filtrationThe obtained solid was collected by filtration
9. washwhile washing with a solvent (hexane:diisopropyl ether=1:1)