Hydrogen chloride-ethyl acetate → N2-(1-(2-(2-oxoquinoxalin-1(2H)-yl)ethyl)piperidin-4-yl)-N-(pyridin-2-yl)glycinamide hydrochloride

HRID 2193160Notes

Reaction equation

HRID 2193160 reaction equation
[O:1]=[C:2]1[CH:11]=[N:10][C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]1[CH2:12][CH2:13][N:14]1[CH2:19][CH2:18][CH:17]([NH:20][CH2:21][C:22]([NH:24][C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][N:26]=2)=[O:23])[CH2:16][CH2:15]1.[ClH:31].C(OCC)(=O)C>C(OCC)(=O)C>[ClH:31].[O:1]=[C:2]1[CH:11]=[N:10][C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]1[CH2:12][CH2:13][N:14]1[CH2:19][CH2:18][CH:17]([NH:20][CH2:21][C:22]([NH:24][C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][N:26]=2)=[O:23])[CH2:16][CH2:15]1

Participants

4

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 59397877HCID 59397877, compound

Product 1

HCID 67538781N2-(1-(2-(2-oxoquinoxalin-1(2H)-yl)ethyl)piperidin-4-yl)-N-(pyridin-2-yl)glycinamide hydrochloride

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent2×

Procedure

To 5 mL of an ethyl acetate solution containing 0.19 g of N2-(1-(2-(2-oxoquinoxalin-1 (2H)-yl)ethyl)piperidin-4-yl)-N-(pyridin-2-yl)glycinamide, mL of 4.0 mol/L hydrogen chloride/ ethyl acetate was added at room temperature. The mixture was stirred at the same temperature for 10 min, and the solvent was removed under reduced pressure. To the residue thus obtained, ethyl acetate was added and the resulting solid was filtered to afford 0.19 g of N2-(1-(2-(2-oxoquinoxalin-1(2H)-yl)ethyl)piperidin-4-yl)-N-(pyridin-2-yl)glycinamide hydrochloride as a yellow solid.

Workup

  1. additionwas added at room temperature
  2. customthe solvent was removed under reduced pressure
  3. customTo the residue thus obtained
  4. filtrationthe resulting solid was filtered

Sources & evidence

ORD record
ord-3004cc7a868149fdae7004593021d6d8
Source dataset
uspto-grants-2012_12
Patent number
US08329694B2

Reaction notes

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