Methanol → HCID 67537339, compound

HRID 2193205Notes

Reaction equation

HRID 2193205 reaction equation
CO.C(OC(=O)[N:9]([CH2:31][C:32]1[CH:41]=[CH:40][C:35]2[O:36][CH2:37][CH2:38][O:39][C:34]=2[CH:33]=1)[CH:10]1[CH2:15][CH2:14][N:13]([CH2:16][CH2:17][N:18]2[C:27]3[C:22](=[CH:23][CH:24]=[C:25]([O:28][CH3:29])[CH:26]=3)[N:21]=[CH:20][C:19]2=[O:30])[CH2:12][CH2:11]1)(C)(C)C.[ClH:43].C(OCC)(=O)C>C(OCC)(=O)C>[ClH:43].[O:36]1[C:35]2[CH:40]=[CH:41][C:32]([CH2:31][NH:9][CH:10]3[CH2:11][CH2:12][N:13]([CH2:16][CH2:17][N:18]4[C:27]5[C:22](=[CH:23][CH:24]=[C:25]([O:28][CH3:29])[CH:26]=5)[N:21]=[CH:20][C:19]4=[O:30])[CH2:14][CH2:15]3)=[CH:33][C:34]=2[O:39][CH2:38][CH2:37]1

Participants

5

Reactant 3

HCID 887MethanolHCID 21866389Hydrogen chloride-ethyl acetateHCID 59398224HCID 59398224, compound

Product 1

HCID 67537339HCID 67537339, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

To 0.5 mL of methanol solution containing 83 mg of tert-butyl(2,3-dihydro-1,4-benzodioxin-6-ylmethyl)(1-(2-(7-methoxy-2-oxoquinoxalin-1(2H)-yl)ethyl)piperidin-4-yl)carbamate, 0.5 mL of 4 mol/L hydrogen chloride/ethyl acetate solution was added, stirred at room temperature for 2 hours, and allowed to stand at the same temperature for 14 hours. Ethyl acetate was added, and the resulting solid was filtered to give 68 mg of 1-(2-(4-((2,3-dihydro-1,4-benzodioxin-6-ylmethyl)amino)piperidin-1-yl)ethyl)-7-methoxyquinoxalin-2(1H)-one hydrochloride as a black solid.

Workup

  1. additionwas added
  2. waitto stand at the same temperature for 14 hours
  3. filtrationthe resulting solid was filtered

Sources & evidence

ORD record
ord-4ef217217ceb4109ab0d2fafa5d5f534
Source dataset
uspto-grants-2012_12
Patent number
US08329694B2

Reaction notes

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