Methanol → HCID 67539457, compound

HRID 2193208Notes

Reaction equation

HRID 2193208 reaction equation
CO.[CH:3]1([C:9]2[CH:18]=[C:17]3[C:12]([C:13]([CH3:47])=[CH:14][C:15](=[O:46])[N:16]3[CH2:19][CH2:20][N:21]3[CH2:26][CH2:25][CH:24]([N:27]([CH2:35][C:36]4[CH:45]=[CH:44][C:39]5[O:40][CH2:41][CH2:42][O:43][C:38]=5[CH:37]=4)C(=O)OC(C)(C)C)[CH2:23][CH2:22]3)=[CH:11][CH:10]=2)[CH2:8][CH2:7][CH2:6][CH2:5][CH2:4]1.[ClH:48].C(OCC)(=O)C>C(OCC)(=O)C>[ClH:48].[CH:3]1([C:9]2[CH:18]=[C:17]3[C:12]([C:13]([CH3:47])=[CH:14][C:15](=[O:46])[N:16]3[CH2:19][CH2:20][N:21]3[CH2:26][CH2:25][CH:24]([NH:27][CH2:35][C:36]4[CH:45]=[CH:44][C:39]5[O:40][CH2:41][CH2:42][O:43][C:38]=5[CH:37]=4)[CH2:23][CH2:22]3)=[CH:11][CH:10]=2)[CH2:8][CH2:7][CH2:6][CH2:5][CH2:4]1

Participants

5

Reactant 3

HCID 887MethanolHCID 21866389Hydrogen chloride-ethyl acetateHCID 59398332HCID 59398332, compound

Product 1

HCID 67539457HCID 67539457, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

To 0.7 mL of methanol solution containing 73 mg of tert-butyl (1-(2-(7-cyclohexyl-4-methyl-2-oxo-1,2-dihydroquinolin-1-yl)ethyl)piperidin-4-yl)(2,3-dihydro-1,4-benzodioxin-6-ylmethyl)carbamate, 0.7 mL of 4 mol/L hydrogen chloride/ethyl acetate solution was added at room temperature, and stirred for 1.5 hours. Ethyl acetate was added, and the resulting solid was filtered to give 43 mg of 7-cyclohexyl-1-(2-(4-((2,3-dihydro-1,4-benzodioxin-6-ylmethyl)amino)piperidin-1-yl)ethyl)-4-methylquinolin-2(1H)-one hydrochloride as a white solid.

Workup

  1. additionwas added at room temperature
  2. filtrationthe resulting solid was filtered

Sources & evidence

ORD record
ord-81266f5d917f4fd28067337203d7c952
Source dataset
uspto-grants-2012_12
Patent number
US08329694B2

Reaction notes

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