Hydrogen chloride-ethyl acetate → HCID 67539414, compound

HRID 2193291Notes

Reaction equation

HRID 2193291 reaction equation
C(OC(=O)[N:7]([CH2:29][C:30]1[CH:39]=[CH:38][C:33]2[O:34][CH2:35][CH2:36][O:37][C:32]=2[CH:31]=1)[CH:8]1[CH2:13][CH2:12][N:11]([CH2:14][CH2:15][N:16]2[C:25]3[C:20](=[CH:21][CH:22]=[C:23]([Cl:26])[CH:24]=3)[C:19]([Cl:27])=[CH:18][C:17]2=[O:28])[CH2:10][CH2:9]1)(C)(C)C.Cl.C(OCC)(=O)C>C(OCC)(=O)C>[ClH:26].[O:34]1[C:33]2[CH:38]=[CH:39][C:30]([CH2:29][NH:7][CH:8]3[CH2:9][CH2:10][N:11]([CH2:14][CH2:15][N:16]4[C:25]5[C:20](=[CH:21][CH:22]=[C:23]([Cl:26])[CH:24]=5)[C:19]([Cl:27])=[CH:18][C:17]4=[O:28])[CH2:12][CH2:13]3)=[CH:31][C:32]=2[O:37][CH2:36][CH2:35]1

Participants

4

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 59398285HCID 59398285, compound

Product 1

HCID 67539414HCID 67539414, compoundYield 133.7%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

To 1 mL of an ethyl acetate solution containing 104 mg of tert-butyl(2,3-dihydro-1,4-benzodioxin-6-ylmethyl)(1-(2-(4,7-dichloro-2-oxoquinolin-1(2H)-yl)ethyl)piperidin-4-yl)carbamate, 2 mL of 4 mol/L hydrogen chloride/ethyl acetate was added, and stirred at room temperature. The resulting solid was filtered to give 62 mg of 1-(2-(4-((2,3-dihydro-1,4-benzodioxin-6-ylmethyl)amino)piperidin-1-yl)ethyl)-4,7-dichloroquinolin-2(1H)-one hydrochloride as a pale yellow solid.

Workup

  1. additionwas added
  2. filtrationThe resulting solid was filtered

Sources & evidence

ORD record
ord-591cec57834a46e2a35e8ad84f18ba1d
Source dataset
uspto-grants-2012_12
Patent number
US08329694B2

Reaction notes

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