Ethyl Acetate → HCID 67538640, compound

HRID 2193313Notes

Reaction equation

HRID 2193313 reaction equation
C(OCC)(=O)C.C(OC(=O)[N:13]([CH:25]1[CH2:30][CH2:29][N:28]([CH2:31][CH2:32][N:33]2[C:42]3[C:37](=[CH:38][CH:39]=[CH:40][CH:41]=3)[C:36]([O:43][CH2:44][C:45]3[CH:50]=[CH:49][CH:48]=[CH:47][CH:46]=3)=[CH:35][C:34]2=[O:51])[CH2:27][CH2:26]1)[CH2:14][C:15]1[CH:24]=[CH:23][C:18]2[O:19][CH2:20][CH2:21][O:22][C:17]=2[CH:16]=1)(C)(C)C.[ClH:53].C(OCC)(=O)C>C(Cl)(Cl)Cl>[ClH:53].[CH2:44]([O:43][C:36]1[C:37]2[C:42](=[CH:41][CH:40]=[CH:39][CH:38]=2)[N:33]([CH2:32][CH2:31][N:28]2[CH2:27][CH2:26][CH:25]([NH:13][CH2:14][C:15]3[CH:24]=[CH:23][C:18]4[O:19][CH2:20][CH2:21][O:22][C:17]=4[CH:16]=3)[CH2:30][CH2:29]2)[C:34](=[O:51])[CH:35]=1)[C:45]1[CH:46]=[CH:47][CH:48]=[CH:49][CH:50]=1

Participants

5

Reactant 3

HCID 8857Ethyl AcetateHCID 21866389Hydrogen chloride-ethyl acetateHCID 59397821HCID 59397821, compound

Product 1

HCID 67538640HCID 67538640, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

To a mixed solution of 1 mL ethyl acetate and 3 mL chloroform containing 0.20 g of tert-butyl(1-(2-(4-benzyloxy-2-oxoquinolin-1(2H)-yl)ethyl)piperidin-4-yl)(2,3-dihydro-1,4-benzodioxin-6-ylmethyl)carbamate, 2 mL of 4 mol/L hydrogen chloride/ethyl acetate was added, and stirred at room temperature for 24 hours, thereafter the resulting solid was filtered to give 0.15 g of 4-benzyloxy-1-(2-(4-((2,3-dihydro-1,4-benzodioxin-6-ylmethyl)amino)piperidin-1-yl)ethyl)quinolin-2(1H)-one hydrochloride as a white solid.

Workup

  1. filtrationthe resulting solid was filtered

Sources & evidence

ORD record
ord-99bcd3a889ab4945a30302b44aa5f1b2
Source dataset
uspto-grants-2012_12
Patent number
US08329694B2

Reaction notes

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