Chloroform → HCID 67539924, compound

HRID 2193356Notes

Reaction equation

HRID 2193356 reaction equation
C(Cl)(Cl)[Cl:2].[S:5]1[C:9]([CH2:10][NH:11][CH:12]2[CH2:17][CH2:16][N:15]([CH2:18][CH2:19][N:20]3[C:29]4[C:24](=[CH:25][CH:26]=[C:27]([O:30][CH3:31])[CH:28]=4)[N:23]=[CH:22][C:21]3=[O:32])[CH2:14][CH2:13]2)=[CH:8][C:7]2[CH:33]=[CH:34][CH:35]=[CH:36][C:6]1=2.Cl.C(OCC)(=O)C>C(OCC)(=O)C>[ClH:2].[S:5]1[C:9]([CH2:10][NH:11][CH:12]2[CH2:17][CH2:16][N:15]([CH2:18][CH2:19][N:20]3[C:29]4[C:24](=[CH:25][CH:26]=[C:27]([O:30][CH3:31])[CH:28]=4)[N:23]=[CH:22][C:21]3=[O:32])[CH2:14][CH2:13]2)=[CH:8][C:7]2[CH:33]=[CH:34][CH:35]=[CH:36][C:6]1=2

Participants

5

Reactant 3

HCID 6212ChloroformHCID 21866389Hydrogen chloride-ethyl acetateHCID 59398117HCID 59398117, compound

Product 1

HCID 67539924HCID 67539924, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

To a mixed solution of 10 mL chloroform and 10 mL ethyl acetate containing 0.52 g of 1-(2-(4-((benzo[b]thiophen-2-yl)methylamino)piperidin-1-yl)ethyl)-7-methoxyquinoxalin-2(1H)-one, 3 mL of 4 mol/L hydrogen chloride/ethyl acetate was added, and stirred at room temperature. The solvent was removed under reduced pressure, ethyl acetate was added and the resulting solid was filtered to give 526 mg of 1-(2-(4-((benzo[b]thiophen-2-yl)methylamino)piperidin-1-yl)ethyl)-7-methoxyquinoxalin-2(1H)-one hydrochloride as a yellow solid.

Workup

  1. customThe solvent was removed under reduced pressure, ethyl acetate
  2. additionwas added
  3. filtrationthe resulting solid was filtered

Sources & evidence

ORD record
ord-97461aa0ff994df5aeb85b454287cea7
Source dataset
uspto-grants-2012_12
Patent number
US08329694B2

Reaction notes

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