Hydrogen chloride-ethyl acetate → HCID 67539363, compound

HRID 2193358Notes

Reaction equation

HRID 2193358 reaction equation
[CH3:1][O:2][C:3]1[CH:12]=[C:11]2[C:6]([N:7]=[CH:8][C:9](=[O:33])[N:10]2[CH2:13][CH2:14][N:15]2[CH2:20][CH2:19][CH:18]([NH:21][CH2:22][C:23]3[CH:27]=[C:26]([C:28]4[S:29][CH:30]=[CH:31][CH:32]=4)[O:25][N:24]=3)[CH2:17][CH2:16]2)=[CH:5][CH:4]=1.[ClH:34].C(OCC)(=O)C>C(OCC)(=O)C>[ClH:34].[CH3:1][O:2][C:3]1[CH:12]=[C:11]2[C:6]([N:7]=[CH:8][C:9](=[O:33])[N:10]2[CH2:13][CH2:14][N:15]2[CH2:20][CH2:19][CH:18]([NH:21][CH2:22][C:23]3[CH:27]=[C:26]([C:28]4[S:29][CH:30]=[CH:31][CH:32]=4)[O:25][N:24]=3)[CH2:17][CH2:16]2)=[CH:5][CH:4]=1

Participants

4

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 593983517-methoxy-1-(2-(4-((5-(thiophen-2-yl)isoxazol-3-yl)methylamino)piperidin-1-yl)ethyl)quinoxalin-2(1H)-one

Product 1

HCID 67539363HCID 67539363, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

To 20 mL of an ethyl acetate solution containing 0.63 g of 7-methoxy-1-(2-(4-((5-(thiophen-2-yl)isoxazol-3-yl)methylamino)piperidin-1-yl)ethyl)quinoxalin-2(1H)-one, 3 mL of 4 mol/L hydrogen chloride/ethyl acetate was added, and stirred at room temperature. The resulting solid was filtered to give 661 mg of 7-methoxy-1-(2-(4-((5-(thiophen-2-yl)isoxazol-3-yl)methylamino)piperidin-1-yl)ethyl)quinoxalin-2(1H)-one hydrochloride as a green solid.

Workup

  1. additionwas added
  2. filtrationThe resulting solid was filtered

Sources & evidence

ORD record
ord-7e23d9c1c95e416f8c9e94ca9c5af9b8
Source dataset
uspto-grants-2012_12
Patent number
US08329694B2

Reaction notes

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