HCID 59397944, compound → HCID 59397863, compound

HRID 2193365Notes

Reaction equation

HRID 2193365 reaction equation
[Br:1][C:2]1[CH:11]=[C:10]2[C:5]([N:6]=[CH:7][C:8](=[O:18])[N:9]2[CH2:12][CH:13]2OCC[O:14]2)=[CH:4][CH:3]=1>FC(F)(F)C(O)=O>[Br:1][C:2]1[CH:11]=[C:10]2[C:5]([N:6]=[CH:7][C:8](=[O:18])[N:9]2[CH2:12][CH:13]=[O:14])=[CH:4][CH:3]=1

Participants

3

Reactant 1

HCID 59397944HCID 59397944, compound

Product 1

HCID 59397863HCID 59397863, compound

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

0.38 g of 7-bromo-1-(1,3-dioxolan-2-ylmethyl)quinoxalin-2(1H)-one was dissolved in 15 mL of 80% aqueous trifluoroacetic acid solution, and stirred at room temperature for 16 hours. After the solvent was removed under reduced pressure, and the reaction mixture was alkalized by adding aqueous saturated sodium hydrogen carbonate solution, it was extracted with ethyl acetate. The organic layer was washed with aqueous saturated sodium chloride solution, dried over anhydrous magnesium sulfate, and the solvent was removed under reduced pressure to give (7-bromo-2-oxoquinoxalin-1(2H)-yl)acetaldehyde.

Workup

  1. customAfter the solvent was removed under reduced pressure
  2. additionby adding aqueous saturated sodium hydrogen carbonate solution, it
  3. extractionwas extracted with ethyl acetate
  4. washThe organic layer was washed with aqueous saturated sodium chloride solution
  5. dry with materialdried over anhydrous magnesium sulfate
  6. customthe solvent was removed under reduced pressure

Sources & evidence

ORD record
ord-b370451583e141babdc16b99f4a4dbec
Source dataset
uspto-grants-2012_12
Patent number
US08329694B2

Reaction notes

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