Hydrogen chloride-ethyl acetate → HCID 67538398, compound

HRID 2193402Notes

Reaction equation

HRID 2193402 reaction equation
[O:1]1[C:10]2[C:5](=[N:6][CH:7]=[C:8]([CH2:11][NH:12][CH:13]3[CH2:18][CH2:17][N:16]([CH2:19][CH2:20][N:21]4[C:30]5[C:25](=[CH:26][CH:27]=[C:28]([O:31][CH3:32])[CH:29]=5)[N:24]=[CH:23][C:22]4=[O:33])[CH2:15][CH2:14]3)[CH:9]=2)[O:4][CH2:3][CH2:2]1.[ClH:34].C(OCC)(=O)C>C(OCC)(=O)C>[ClH:34].[O:1]1[C:10]2[C:5](=[N:6][CH:7]=[C:8]([CH2:11][NH:12][CH:13]3[CH2:18][CH2:17][N:16]([CH2:19][CH2:20][N:21]4[C:30]5[C:25](=[CH:26][CH:27]=[C:28]([O:31][CH3:32])[CH:29]=5)[N:24]=[CH:23][C:22]4=[O:33])[CH2:15][CH2:14]3)[CH:9]=2)[O:4][CH2:3][CH2:2]1

Participants

4

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 59397970HCID 59397970, compound

Product 1

HCID 67538398HCID 67538398, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

To 4 mL of an ethyl acetate solution containing 160 mg of 1-(2-(4-((2,3-dihydro-1,4-dioxino[2,3-b]pyridin-7-yl)methylamino)piperidin-1-yl)ethyl)-7-methoxyquinoxalin-2(1H)-one, 2 mL of 4 mol/L hydrogen chloride/ethyl acetate was added, and stirred at room temperature. The resulting solid was filtered to give 166 mg of 1-(2-(4-((2,3-dihydro-1,4-dioxino[2,3-b]pyridin-7-yl)methylamino)piperidin-1-yl)ethyl)-7-methoxyquinoxalin-2(1H)-one hydrochloride as a white powder.

Workup

  1. additionwas added
  2. filtrationThe resulting solid was filtered

Sources & evidence

ORD record
ord-e0df470843834d7f86cbc5dfef4c98af
Source dataset
uspto-grants-2012_12
Patent number
US08329694B2

Reaction notes

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