4-Chlorophenyl Isocyanate → HCID 66661923, compound

HRID 2193473Notes

Reaction equation

HRID 2193473 reaction equation
[CH2:1]([O:4][C:5]([N:7]1[CH2:12][CH2:11][C:10]2[C:13]([C:17](=[O:19])[NH2:18])=[C:14]([NH2:16])[S:15][C:9]=2[CH2:8]1)=[O:6])[CH:2]=[CH2:3].[Cl:20][C:21]1[CH:26]=[CH:25][C:24]([N:27]=[C:28]=[O:29])=[CH:23][CH:22]=1>N1C=CC=CC=1>[CH2:1]([O:4][C:5]([N:7]1[CH2:12][CH2:11][C:10]2[C:13]([C:17](=[O:19])[NH2:18])=[C:14]([NH:16][C:28]([NH:27][C:24]3[CH:25]=[CH:26][C:21]([Cl:20])=[CH:22][CH:23]=3)=[O:29])[S:15][C:9]=2[CH2:8]1)=[O:6])[CH:2]=[CH2:3]

Participants

4

Reactant 2

HCID 76934-Chlorophenyl IsocyanateHCID 58056911HCID 58056911, compound

Product 1

HCID 66661923HCID 66661923, compoundYield 46%

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

Starting material 8 (1 g, 3.6 mmol) was dissolved in 12 ml of pyridine and p-chlorphenyl isocyanate (546 mg, 3.6 mmol) was added. The red solution was stirred over the weekend. The solvent was reduced in a vacuum centrifuge. The crude product was used without further purification (green-brown solid, 1.13 g, 65% content 9, 46% yield).

Workup

  1. customThe crude product was used without further purification (green-brown solid, 1.13 g, 65% content 9, 46% yield)

Sources & evidence

ORD record
ord-3515c5d8e048488d9b68b8d461c35f84
Source dataset
uspto-grants-2012_12
Patent number
US08329907B2

Reaction notes

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