HCID 11166034, compound → HCID 11255641, compound

HRID 2193554Notes

Reaction equation

HRID 2193554 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[CH:19]=[CH:18][C:17]([N:20]3[CH2:24][C@H:23]([CH2:25][NH:26][C:27](=[O:29])[CH3:28])[O:22][C:21]3=[O:30])=[CH:16][N:15]=2)[CH2:10][CH2:9]1)=O)(C)(C)C>Cl.CO>[O:30]=[C:21]1[N:20]([C:17]2[CH:16]=[N:15][C:14]([N:11]3[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]3)=[CH:19][CH:18]=2)[CH2:24][C@H:23]([CH2:25][NH:26][C:27](=[O:29])[CH3:28])[O:22]1

Participants

4

Reactant 1

HCID 11166034HCID 11166034, compound

Product 1

HCID 11255641HCID 11255641, compound

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidSolventHCID 887MethanolSolvent

Procedure

0.54 g of 4-{5-[(5S)-5-(acetylamino-methyl)-2-oxo-oxazolidin-3-yl]-pyridin-2-yl}-piperazine-1-carboxylic acid tert-butyl ester (1.28 mmol) was dissolved in a 1.25 M HCl solution in methanol. The solution was stirred and the reaction monitored by TLC. The methanol was evaporated, the residue dissolved in water, neutralized with sodium bicarbonate and the water evaporated to dryness. The residue was digested in a 9/1 dichloromethane/methanol. The insoluble salt was filtered off, the filtrate evaporated to dryness to leave a pale brown solid.

Workup

  1. customThe methanol was evaporated
  2. dissolutionthe residue dissolved in water
  3. customthe water evaporated to dryness
  4. filtrationThe insoluble salt was filtered off
  5. customthe filtrate evaporated to dryness
  6. customto leave a pale brown solid

Sources & evidence

ORD record
ord-49042a8b334242cfb869a9c97f84e1a1
Source dataset
uspto-grants-2012_12
Patent number
US08329908B2

Reaction notes

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