反应详情

A solution of 105 (42 mg, 0.0648 mmol) in TFA (1 ml) was stirred at RT for 30 mins. The TFA was removed by evaporation and then 4N HCl in dioxane (0.5 ml) was added and the mixture was concentrated to dryness. The residual solid was triturated with diethyl ether to afford title compound 102 (38 mg, 100% yield). MS (m/z): 518.1 (M+H).

1. customThe TFA was removed by evaporation
2. addition4N HCl in dioxane (0.5 ml) was added
3. concentrationthe mixture was concentrated to dryness
4. customThe residual solid was triturated with diethyl ether