4-Fluoroaniline → 1-[(4-Fluorophenyl)carbamoyl]cyclopropanecarboxylic Acid

HRID 2193726Notes

Reaction equation

[C:1]1([NH:7][C:8]([C:10]2([C:13]([OH:15])=[O:14])[CH2:12][CH2:11]2)=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[F:16]C1C=CC(N)=CC=1>>[F:16][C:4]1[CH:3]=[CH:2][C:1]([NH:7][C:8]([C:10]2([C:13]([OH:15])=[O:14])[CH2:11][CH2:12]2)=[O:9])=[CH:6][CH:5]=1

Participants

Reactant 2

HCID 97314-Fluoroaniline

HCID 190968711-(Phenylcarbamoyl)cyclopropanecarboxylic acid

Product 1

HCID 210815301-[(4-Fluorophenyl)carbamoyl]cyclopropanecarboxylic AcidYield 57%

Procedure

Following the procedure described above for the compound 161 (scheme 45), but replacing aniline for 4-fluoroaniline, title compound 181 was obtained in 57% yield. MS (m/z): 224.0 (M+H).

Sources & evidence

ORD record: ord-10603b30188d4307aa5141635e72ac86
Source dataset: uspto-grants-2012_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08329726B2

Reaction notes

Loading…