HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonium Chloride → 3-Fluoro-4-(2-(5-((4-methylpiperazin-1-yl)methyl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yloxy)aniline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonium Chloride | HCID 25517 | — |
| Reactant | 7-(2-Fluoro-4-nitrophenoxy)-2-(5-((4-methylpiperazin-1-yl)methyl)pyridin-2-yl)thieno[3,2-b]pyridine | HCID 59457710 | — |
| Catalyst | Iron | HCID 23925 | — |
| Solvent | Water ethanol | HCID 19096565 | — |
| Product | 3-Fluoro-4-(2-(5-((4-methylpiperazin-1-yl)methyl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yloxy)aniline | HCID 59457721 | 100% |
Reaction Steps
To a solution of 401 (306 mg, 0.64 mmol) and NH4Cl (30 mg, 0.54 mmol) in 2:1 EtOH/water (10.5 mL) was added iron powder (304 mg, 5.43 mmol) and the suspension was heated to reflux for 1 hour. The reaction mixture was filtered through celite and concentrated to provide title compound 396, that was used without further purification (343 mg, 100% yield). MS (m/z): (M+1) 450.0 (100%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08329726B2 |
| Source dataset | uspto-grants-2012_12 |
| ORD ID | ord-19ac366a1524491fa50a79140455c1e8 |
| Source note | uspto-grants-2012_12 |