2-Thiophenesulfonyl chloride → HCID 49802795, compound

HRID 2194027Notes

Reaction equation

HRID 2194027 reaction equation
C(O[C:4]([C:6]1([CH2:12][CH2:13]OC)[CH2:11][CH2:10][NH:9][CH2:8][CH2:7]1)=[O:5])C.[S:16]1[CH:20]=[CH:19][CH:18]=[C:17]1[S:21](Cl)(=[O:23])=[O:22].[CH:25]1([C:28]2[CH:34]=[CH:33][C:31]([NH2:32])=[CH:30][CH:29]=2)[CH2:27][CH2:26]1>>[CH:25]1([C:28]2[CH:34]=[CH:33][C:31]([N:32]3[CH2:13][CH2:12][C:6]4([CH2:7][CH2:8][N:9]([S:21]([C:17]5[S:16][CH:20]=[CH:19][CH:18]=5)(=[O:23])=[O:22])[CH2:10][CH2:11]4)[C:4]3=[O:5])=[CH:30][CH:29]=2)[CH2:27][CH2:26]1

Participants

4

Reactant 3

HCID 855182-Thiophenesulfonyl chlorideHCID 122539274-CyclopropylanilineHCID 567539694-(2-Methoxy-ethyl)-piperidine-4-carboxylic acid ethyl ester

Product 1

HCID 49802795HCID 49802795, compound

Procedure

Light brown solid. MS (ESI): 417.13 (MH+). This example was prepared in analogy to example 1 step C) to D) from 4-(2-methoxy-ethyl)-piperidine-4-carboxylic acid ethyl ester (example 1 step B)), thiophene-2-sulfonyl chloride and 4-cyclopropyl-aniline.

Sources & evidence

ORD record
ord-1c5ac429168944f3a0ad3fe74a7cecac
Source dataset
uspto-grants-2012_12
Patent number
US08329904B2

Reaction notes

Loading…