2-Thiophenesulfonyl chloride → HCID 49803070, compound

HRID 2194034Notes

Reaction equation

HRID 2194034 reaction equation
C(O[C:4]([C:6]1([CH2:12][CH2:13]OC)[CH2:11][CH2:10][NH:9][CH2:8][CH2:7]1)=[O:5])C.[S:16]1[CH:20]=[CH:19][CH:18]=[C:17]1[S:21](Cl)(=[O:23])=[O:22].[CH:25]([C:29]1[CH:34]=[CH:33][C:32]([NH2:35])=[CH:31][CH:30]=1)([CH2:27][CH3:28])[CH3:26]>>[CH:25]([C:29]1[CH:30]=[CH:31][C:32]([N:35]2[CH2:13][CH2:12][C:6]3([CH2:7][CH2:8][N:9]([S:21]([C:17]4[S:16][CH:20]=[CH:19][CH:18]=4)(=[O:23])=[O:22])[CH2:10][CH2:11]3)[C:4]2=[O:5])=[CH:33][CH:34]=1)([CH2:27][CH3:28])[CH3:26]

Participants

4

Reactant 3

HCID 855182-Thiophenesulfonyl chlorideHCID 121771Benzenamine, 4-(1-methylpropyl)-HCID 567539694-(2-Methoxy-ethyl)-piperidine-4-carboxylic acid ethyl ester

Product 1

HCID 49803070HCID 49803070, compound

Procedure

Off-white solid. MS (ESI): 433.16 (MH+). This example was prepared in analogy to example 1 step C) to D) from 4-(2-methoxy-ethyl)-piperidine-4-carboxylic acid ethyl ester (example 1 step B)), thiophene-2-sulphonyl chloride and 4-sec-butyl-phenylamine.

Sources & evidence

ORD record
ord-ef809711370847cf97db4fd646ad80fb
Source dataset
uspto-grants-2012_12
Patent number
US08329904B2

Reaction notes

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