5-Methylthiophene-2-sulfonyl chloride → Methanesulfonic acid 4-[8-(5-methyl-thiophene-2-sulfonyl)-1-oxo-2,8-diaza-spiro[4.5]dec-2-yl]-phenyl ester

HRID 2194040Notes

Reaction equation

HRID 2194040 reaction equation
C(O[C:4]([C:6]1([CH2:12][CH2:13]OC)[CH2:11][CH2:10][NH:9][CH2:8][CH2:7]1)=[O:5])C.[CH3:16][C:17]1[S:21][C:20]([S:22](Cl)(=[O:24])=[O:23])=[CH:19][CH:18]=1.[NH2:26][C:27]1[CH:32]=[CH:31][C:30]([O:33][S:34]([CH3:37])(=[O:36])=[O:35])=[CH:29][CH:28]=1>>[CH3:16][C:17]1[S:21][C:20]([S:22]([N:9]2[CH2:8][CH2:7][C:6]3([C:4](=[O:5])[N:26]([C:27]4[CH:32]=[CH:31][C:30]([O:33][S:34]([CH3:37])(=[O:36])=[O:35])=[CH:29][CH:28]=4)[CH2:13][CH2:12]3)[CH2:11][CH2:10]2)(=[O:24])=[O:23])=[CH:19][CH:18]=1

Participants

4

Reactant 3

HCID 124001125-Methylthiophene-2-sulfonyl chlorideHCID 19885019Phenol, 4-amino-, 1-methanesulfonateHCID 567539694-(2-Methoxy-ethyl)-piperidine-4-carboxylic acid ethyl ester

Product 1

HCID 49803344Methanesulfonic acid 4-[8-(5-methyl-thiophene-2-sulfonyl)-1-oxo-2,8-diaza-spiro[4.5]dec-2-yl]-phenyl ester

Procedure

Brown solid. MS (ESI): 485.08 (MH+). This example was prepared in analogy to example 1 step C) to D) from 4-(2-methoxy-ethyl)-piperidine-4-carboxylic acid ethyl ester (example 1 step B)), 5-methylthiophene-2-sulphonyl chloride and methanesulfonic acid 4-amino-phenyl ester.

Sources & evidence

ORD record
ord-2fed466c47eb4c64a293ca911cb734f7
Source dataset
uspto-grants-2012_12
Patent number
US08329904B2

Reaction notes

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