HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Methylthiophene-2-sulfonyl chloride → Methanesulfonic acid 4-[8-(5-methyl-thiophene-2-sulfonyl)-1-oxo-2,8-diaza-spiro[4.5]dec-2-yl]-phenyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Methylthiophene-2-sulfonyl chloride | HCID 12400112 | — |
| Reactant | Phenol, 4-amino-, 1-methanesulfonate | HCID 19885019 | — |
| Reactant | 4-(2-Methoxy-ethyl)-piperidine-4-carboxylic acid ethyl ester | HCID 56753969 | — |
| Product | Methanesulfonic acid 4-[8-(5-methyl-thiophene-2-sulfonyl)-1-oxo-2,8-diaza-spiro[4.5]dec-2-yl]-phenyl ester | HCID 49803344 | — |
Reaction Steps
Brown solid. MS (ESI): 485.08 (MH+). This example was prepared in analogy to example 1 step C) to D) from 4-(2-methoxy-ethyl)-piperidine-4-carboxylic acid ethyl ester (example 1 step B)), 5-methylthiophene-2-sulphonyl chloride and methanesulfonic acid 4-amino-phenyl ester.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08329904B2 |
| Source dataset | uspto-grants-2012_12 |
| ORD ID | ord-2fed466c47eb4c64a293ca911cb734f7 |
| Source note | uspto-grants-2012_12 |