2,2-Dimethylpropane-1-sulfonyl chloride → Methanesulfonic acid 4-[8-(2,2-dimethyl-propane-1-sulfonyl)-1-oxo-2,8-diaza-spiro[4.5]dec-2-yl]-phenyl ester

HRID 2194043Notes

Reaction equation

HRID 2194043 reaction equation
C(O[C:4]([C:6]1([CH2:12][CH2:13]OC)[CH2:11][CH2:10][NH:9][CH2:8][CH2:7]1)=[O:5])C.[CH3:16][C:17]([CH3:24])([CH3:23])[CH2:18][S:19](Cl)(=[O:21])=[O:20].[NH2:25][C:26]1[CH:31]=[CH:30][C:29]([O:32][S:33]([CH3:36])(=[O:35])=[O:34])=[CH:28][CH:27]=1>>[CH3:16][C:17]([CH3:24])([CH3:23])[CH2:18][S:19]([N:9]1[CH2:8][CH2:7][C:6]2([C:4](=[O:5])[N:25]([C:26]3[CH:31]=[CH:30][C:29]([O:32][S:33]([CH3:36])(=[O:35])=[O:34])=[CH:28][CH:27]=3)[CH2:13][CH2:12]2)[CH2:11][CH2:10]1)(=[O:21])=[O:20]

Participants

4

Reactant 3

HCID 125746322,2-Dimethylpropane-1-sulfonyl chlorideHCID 19885019Phenol, 4-amino-, 1-methanesulfonateHCID 567539694-(2-Methoxy-ethyl)-piperidine-4-carboxylic acid ethyl ester

Product 1

HCID 49803632Methanesulfonic acid 4-[8-(2,2-dimethyl-propane-1-sulfonyl)-1-oxo-2,8-diaza-spiro[4.5]dec-2-yl]-phenyl ester

Procedure

Off-white solid. MS (ESI): 459.16 (MH+). This example was prepared in analogy to example 1 step C) to D) from 4-(2-methoxy-ethyl)-piperidine-4-carboxylic acid ethyl ester (example 1 step B)), 2,2-dimethyl-propane-1-sulfonyl chloride and methanesulfonic acid 4-amino-phenyl ester.

Sources & evidence

ORD record
ord-c6bed409dc86417787511906c815739b
Source dataset
uspto-grants-2012_12
Patent number
US08329904B2

Reaction notes

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