HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,2-Dimethylpropane-1-sulfonyl chloride → Methanesulfonic acid 4-[8-(2,2-dimethyl-propane-1-sulfonyl)-1-oxo-2,8-diaza-spiro[4.5]dec-2-yl]-phenyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,2-Dimethylpropane-1-sulfonyl chloride | HCID 12574632 | — |
| Reactant | Phenol, 4-amino-, 1-methanesulfonate | HCID 19885019 | — |
| Reactant | 4-(2-Methoxy-ethyl)-piperidine-4-carboxylic acid ethyl ester | HCID 56753969 | — |
| Product | Methanesulfonic acid 4-[8-(2,2-dimethyl-propane-1-sulfonyl)-1-oxo-2,8-diaza-spiro[4.5]dec-2-yl]-phenyl ester | HCID 49803632 | — |
Reaction Steps
Off-white solid. MS (ESI): 459.16 (MH+). This example was prepared in analogy to example 1 step C) to D) from 4-(2-methoxy-ethyl)-piperidine-4-carboxylic acid ethyl ester (example 1 step B)), 2,2-dimethyl-propane-1-sulfonyl chloride and methanesulfonic acid 4-amino-phenyl ester.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08329904B2 |
| Source dataset | uspto-grants-2012_12 |
| ORD ID | ord-c6bed409dc86417787511906c815739b |
| Source note | uspto-grants-2012_12 |