2-Thiophenesulfonyl chloride → HCID 49803924, compound

HRID 2194049Notes

Reaction equation

HRID 2194049 reaction equation
C(O[C:4]([C:6]1([CH2:12][CH2:13]OC)[CH2:11][CH2:10][NH:9][CH2:8][CH2:7]1)=[O:5])C.[S:16]1[CH:20]=[CH:19][CH:18]=[C:17]1[S:21](Cl)(=[O:23])=[O:22].[NH2:25][C:26]1[CH:31]=[CH:30][C:29]([O:32][S:33]([CH3:36])(=[O:35])=[O:34])=[CH:28][CH:27]=1>>[O:5]=[C:4]1[C:6]2([CH2:7][CH2:8][N:9]([S:21]([C:17]3[S:16][CH:20]=[CH:19][CH:18]=3)(=[O:23])=[O:22])[CH2:10][CH2:11]2)[CH2:12][CH2:13][N:25]1[C:26]1[CH:31]=[CH:30][C:29]([O:32][S:33]([CH3:36])(=[O:35])=[O:34])=[CH:28][CH:27]=1

Participants

4

Reactant 3

HCID 855182-Thiophenesulfonyl chlorideHCID 19885019Phenol, 4-amino-, 1-methanesulfonateHCID 567539694-(2-Methoxy-ethyl)-piperidine-4-carboxylic acid ethyl ester

Product 1

HCID 49803924HCID 49803924, compound

Procedure

Off-white solid. MS (ESI): 471.07 (MH+). This example was prepared in analogy to example 1 step C) to D) from 4-(2-methoxy-ethyl)-piperidine-4-carboxylic acid ethyl ester (example 1 step B)), thiophene-2-sulphonyl chloride and methanesulfonic acid 4-amino-phenyl ester.

Sources & evidence

ORD record
ord-841652c871984d958c5d3b31d427e49a
Source dataset
uspto-grants-2012_12
Patent number
US08329904B2

Reaction notes

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