1-Propanesulfonyl chloride, 2-methyl- → 8-(2-Methyl-propane-1-sulfonyl)-2-[4-(2,2,2-trifluoro-ethyl)-phenyl]-2,8-diaza-spiro[4.5]decan-1-one
Reaction equation
C(O[C:4]([C:6]1([CH2:12][CH2:13]OC)[CH2:11][CH2:10][NH:9][CH2:8][CH2:7]1)=[O:5])C.[CH3:16][CH:17]([CH3:23])[CH2:18][S:19](Cl)(=[O:21])=[O:20].[F:24][C:25]([F:35])([F:34])[CH2:26][C:27]1[CH:32]=[CH:31][C:30]([NH2:33])=[CH:29][CH:28]=1>>[CH3:16][CH:17]([CH3:23])[CH2:18][S:19]([N:9]1[CH2:8][CH2:7][C:6]2([C:4](=[O:5])[N:33]([C:30]3[CH:31]=[CH:32][C:27]([CH2:26][C:25]([F:24])([F:34])[F:35])=[CH:28][CH:29]=3)[CH2:13][CH2:12]2)[CH2:11][CH2:10]1)(=[O:21])=[O:20]Participants
4
Procedure
White crystalline solid. MS (ESI): 433.19 (MH+). This example was prepared in analogy to example 1 step C) to D) from 4-(2-methoxy-ethyl)-piperidine-4-carboxylic acid ethyl ester (example 1 step B)), 2-methyl-propane-1-sulfonyl chloride and 4-(2,2,2-trifluoro-ethyl)-phenylamine.
Sources & evidence
- ORD record
- ord-eb09e6b31cfb433782978fbe30b9b0c7
- Source dataset
- uspto-grants-2012_12
- Patent number
- US08329904B2
Reaction notes
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