HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Propanesulfonyl chloride, 2-methyl- → 8-(2-Methyl-propane-1-sulfonyl)-2-[4-(2,2,2-trifluoro-ethyl)-phenyl]-2,8-diaza-spiro[4.5]decan-1-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Propanesulfonyl chloride, 2-methyl- | HCID 182236 | — |
| Reactant | 4-(2,2,2-Trifluoroethyl)aniline | HCID 14836858 | — |
| Reactant | 4-(2-Methoxy-ethyl)-piperidine-4-carboxylic acid ethyl ester | HCID 56753969 | — |
| Product | 8-(2-Methyl-propane-1-sulfonyl)-2-[4-(2,2,2-trifluoro-ethyl)-phenyl]-2,8-diaza-spiro[4.5]decan-1-one | HCID 49803925 | — |
Reaction Steps
White crystalline solid. MS (ESI): 433.19 (MH+). This example was prepared in analogy to example 1 step C) to D) from 4-(2-methoxy-ethyl)-piperidine-4-carboxylic acid ethyl ester (example 1 step B)), 2-methyl-propane-1-sulfonyl chloride and 4-(2,2,2-trifluoro-ethyl)-phenylamine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08329904B2 |
| Source dataset | uspto-grants-2012_12 |
| ORD ID | ord-eb09e6b31cfb433782978fbe30b9b0c7 |
| Source note | uspto-grants-2012_12 |