4-Ethylaniline → 2-(4-Ethyl-phenyl)-8-(4-fluoro-2-trifluoromethyl-benzenesulfonyl)-2,8-diaza-spiro[4.5]decan-1-one
Reaction equation
C(O[C:4]([C:6]1([CH2:12][CH2:13]OC)[CH2:11][CH2:10][NH:9][CH2:8][CH2:7]1)=[O:5])C.[F:16][C:17]1[CH:22]=[CH:21][C:20]([S:23](Cl)(=[O:25])=[O:24])=[C:19]([C:27]([F:30])([F:29])[F:28])[CH:18]=1.[CH2:31]([C:33]1[CH:39]=[CH:38][C:36]([NH2:37])=[CH:35][CH:34]=1)[CH3:32]>>[CH2:31]([C:33]1[CH:39]=[CH:38][C:36]([N:37]2[CH2:13][CH2:12][C:6]3([CH2:7][CH2:8][N:9]([S:23]([C:20]4[CH:21]=[CH:22][C:17]([F:16])=[CH:18][C:19]=4[C:27]([F:30])([F:29])[F:28])(=[O:25])=[O:24])[CH2:10][CH2:11]3)[C:4]2=[O:5])=[CH:35][CH:34]=1)[CH3:32]Participants
4
Procedure
Off-white solid. MS (ESI): 485.15 (MH+). This example was prepared in analogy to example 1 step C) to D) from 4-(2-methoxy-ethyl)-piperidine-4-carboxylic acid ethyl ester (example 1 step B)), 4-fluoro-2-trifluoromethyl-benzenesulfonyl chloride and 4-ethyl-aniline.
Sources & evidence
- ORD record
- ord-33f7a868f0ca42a0813335806885c884
- Source dataset
- uspto-grants-2012_12
- Patent number
- US08329904B2
Reaction notes
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