HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Ethylaniline → 2-(4-Ethyl-phenyl)-8-(4-fluoro-2-trifluoromethyl-benzenesulfonyl)-2,8-diaza-spiro[4.5]decan-1-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Ethylaniline | HCID 11504 | — |
| Reactant | 4-Fluoro-2-(trifluoromethyl)benzenesulfonyl Chloride | HCID 2737548 | — |
| Reactant | 4-(2-Methoxy-ethyl)-piperidine-4-carboxylic acid ethyl ester | HCID 56753969 | — |
| Product | 2-(4-Ethyl-phenyl)-8-(4-fluoro-2-trifluoromethyl-benzenesulfonyl)-2,8-diaza-spiro[4.5]decan-1-one | HCID 49800222 | — |
Reaction Steps
Off-white solid. MS (ESI): 485.15 (MH+). This example was prepared in analogy to example 1 step C) to D) from 4-(2-methoxy-ethyl)-piperidine-4-carboxylic acid ethyl ester (example 1 step B)), 4-fluoro-2-trifluoromethyl-benzenesulfonyl chloride and 4-ethyl-aniline.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08329904B2 |
| Source dataset | uspto-grants-2012_12 |
| ORD ID | ord-33f7a868f0ca42a0813335806885c884 |
| Source note | uspto-grants-2012_12 |