HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-(Trifluoromethoxy)benzene-1-sulfonyl chloride → Cyclopropanesulfonic acid 4-[1-oxo-8-(2-trifluoromethoxy-benzenesulfonyl)-2,8-diaza-spiro[4.5]dec-2-yl]-phenyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-(Trifluoromethoxy)benzene-1-sulfonyl chloride | HCID 2777215 | — |
| Reactant | 4-(2-Methoxy-ethyl)-piperidine-4-carboxylic acid ethyl ester | HCID 56753969 | — |
| Reactant | HCID 86647649 | HCID 86647649 | — |
| Product | Cyclopropanesulfonic acid 4-[1-oxo-8-(2-trifluoromethoxy-benzenesulfonyl)-2,8-diaza-spiro[4.5]dec-2-yl]-phenyl ester | HCID 49800499 | — |
Reaction Steps
Light brown solid. MS (ESI): 575.11 (MH+). This example was prepared in analogy to example 1 step C) to D) from 4-(2-methoxy-ethyl)-piperidine-4-carboxylic acid ethyl ester (example 1 step B)), 2-trifluoromethoxy-benzenesulfonyl chloride and cyclopropanesulfonic acid 4-amino-phenyl ester.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08329904B2 |
| Source dataset | uspto-grants-2012_12 |
| ORD ID | ord-344b677229814217a6d2887d36d78e4b |
| Source note | uspto-grants-2012_12 |