2-Chlorobenzenesulfonyl chloride → HCID 59577989, compound

HRID 2194108Notes

Reaction equation

HRID 2194108 reaction equation
C(O[C:4]([C:6]1([CH2:12][CH2:13]OC)[CH2:11][CH2:10][NH:9][CH2:8][CH2:7]1)=[O:5])C.[Cl:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=1[S:23](Cl)(=[O:25])=[O:24].[CH2:27]([N:29]1[C:37]2[C:32](=[CH:33][C:34]([NH2:38])=[CH:35][CH:36]=2)[CH:31]=[N:30]1)[CH3:28]>>[Cl:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=1[S:23]([N:9]1[CH2:8][CH2:7][C:6]2([C:4](=[O:5])[N:38]([C:34]3[CH:33]=[C:32]4[C:37](=[CH:36][CH:35]=3)[N:29]([CH2:27][CH3:28])[N:30]=[CH:31]4)[CH2:13][CH2:12]2)[CH2:11][CH2:10]1)(=[O:25])=[O:24]

Participants

4

Reactant 3

HCID 761872-Chlorobenzenesulfonyl chlorideHCID 53393794HCID 53393794, compoundHCID 567539694-(2-Methoxy-ethyl)-piperidine-4-carboxylic acid ethyl ester

Product 1

HCID 59577989HCID 59577989, compound

Procedure

Light brown crystalline solid. MS (ESI): 473.2 (MH+). This example was prepared in analogy to example 1 step C) to D) from 4-(2-methoxy-ethyl)-piperidine-4-carboxylic acid ethyl ester (example 1 step B)), 2-chlorobenzenesulfonyl chloride and 1-ethyl-1H-indazol-5-ylamine (for synthesis: Chakrabarty et al. Tetrahedron; 64; 2008; 6711).

Sources & evidence

ORD record
ord-da76ef01e15c49bba3ed5ff97951d4ea
Source dataset
uspto-grants-2012_12
Patent number
US08329904B2

Reaction notes

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