2-Chlorobenzenesulfonyl chloride → HCID 59578077, compound

HRID 2194111Notes

Reaction equation

HRID 2194111 reaction equation
C(O[C:4]([C:6]1([CH2:12][CH2:13]OC)[CH2:11][CH2:10][NH:9][CH2:8][CH2:7]1)=[O:5])C.[Cl:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=1[S:23](Cl)(=[O:25])=[O:24].[CH3:27][N:28]1[C:36]2[C:31](=[CH:32][C:33]([NH2:37])=[CH:34][CH:35]=2)[CH:30]=[N:29]1>>[Cl:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=1[S:23]([N:9]1[CH2:8][CH2:7][C:6]2([C:4](=[O:5])[N:37]([C:33]3[CH:32]=[C:31]4[C:36](=[CH:35][CH:34]=3)[N:28]([CH3:27])[N:29]=[CH:30]4)[CH2:13][CH2:12]2)[CH2:11][CH2:10]1)(=[O:25])=[O:24]

Participants

4

Reactant 3

HCID 761872-Chlorobenzenesulfonyl chlorideHCID 27680321-methyl-1H-indazol-5-amineHCID 567539694-(2-Methoxy-ethyl)-piperidine-4-carboxylic acid ethyl ester

Product 1

HCID 59578077HCID 59578077, compound

Procedure

Light brown crystalline solid. MS (ESI): 459.4 (MH+). This example was prepared in analogy to example 1 step C) to D) from 4-(2-methoxy-ethyl)-piperidine-4-carboxylic acid ethyl ester (example 1 step B)), 2-chlorobenzenesulfonyl chloride and 1-methyl-1H-indazol-5-ylamine (synthesis: Fries et al, Justus Liebigs Annalen der Chemie; 454; 1927; 306).

Sources & evidence

ORD record
ord-1b0c58deade04d20a3062e2c0176a300
Source dataset
uspto-grants-2012_12
Patent number
US08329904B2

Reaction notes

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