1-Chloro-2-iodo-4-(trifluoromethyl)benzene → 8-(2-Chloro-benzenesulfonyl)-2-(2-chloro-5-trifluoromethyl-phenyl)-2,8-diaza-spiro[4.5]decan-1-one
Reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[S:8]([N:11]1[CH2:21][CH2:20][C:14]2([C:18](=[O:19])[NH:17][CH2:16][CH2:15]2)[CH2:13][CH2:12]1)(=[O:10])=[O:9].[Cl:22][C:23]1[CH:28]=[CH:27][C:26]([C:29]([F:32])([F:31])[F:30])=[CH:25][C:24]=1I>>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[S:8]([N:11]1[CH2:21][CH2:20][C:14]2([C:18](=[O:19])[N:17]([C:24]3[CH:25]=[C:26]([C:29]([F:31])([F:32])[F:30])[CH:27]=[CH:28][C:23]=3[Cl:22])[CH2:16][CH2:15]2)[CH2:13][CH2:12]1)(=[O:9])=[O:10]Participants
3
Procedure
This material was prepared in analogy to example 148 step F) from 8-(2-chloro-benzenesulfonyl)-2,8-diaza-spiro[4.5]decan-1-one and 1-chloro-2-iodo-4-trifluoromethyl-benzene. White solid. MS (ESI): 507.0 MH+).
Sources & evidence
- ORD record
- ord-eacbba40a5494724b632baa814209145
- Source dataset
- uspto-grants-2012_12
- Patent number
- US08329904B2
Reaction notes
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