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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2194137Generated: October 30, 2026

1-Chloro-2-iodo-4-(trifluoromethyl)benzene → 8-(2-Chloro-benzenesulfonyl)-2-(2-chloro-5-trifluoromethyl-phenyl)-2,8-diaza-spiro[4.5]decan-1-one

https://huagongshe.com/reaction/2194137

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-Chloro-2-iodo-4-(trifluoromethyl)benzeneHCID 69596—
Reactant8-(2-Chloro-benzenesulfonyl)-2,8-diaza-spiro[4.5]decan-1-oneHCID 59577994—
Product8-(2-Chloro-benzenesulfonyl)-2-(2-chloro-5-trifluoromethyl-phenyl)-2,8-diaza-spiro[4.5]decan-1-oneHCID 59577927—

Reaction Steps

This material was prepared in analogy to example 148 step F) from 8-(2-chloro-benzenesulfonyl)-2,8-diaza-spiro[4.5]decan-1-one and 1-chloro-2-iodo-4-trifluoromethyl-benzene. White solid. MS (ESI): 507.0 MH+).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08329904B2
Source datasetuspto-grants-2012_12
ORD IDord-eacbba40a5494724b632baa814209145
Source noteuspto-grants-2012_12