2,2,2-Trifluoro-1-(4-iodophenyl)ethanol → 2-(4-(2,2,2-Trifluoro-1-hydroxyethyl)phenyl)-8-(2-(trifluoromethyl)phenylsulfonyl)-2,8-diazaspiro[4.5]decan-1-one

HRID 2194147Notes

Reaction equation

HRID 2194147 reaction equation
[F:1][C:2]([F:24])([F:23])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[S:9]([N:12]1[CH2:22][CH2:21][C:15]2([C:19](=[O:20])[NH:18][CH2:17][CH2:16]2)[CH2:14][CH2:13]1)(=[O:11])=[O:10].[F:25][C:26]([F:37])([F:36])[CH:27]([C:29]1[CH:34]=[CH:33][C:32](I)=[CH:31][CH:30]=1)[OH:28]>>[F:25][C:26]([F:36])([F:37])[CH:27]([C:29]1[CH:34]=[CH:33][C:32]([N:18]2[CH2:17][CH2:16][C:15]3([CH2:21][CH2:22][N:12]([S:9]([C:4]4[CH:5]=[CH:6][CH:7]=[CH:8][C:3]=4[C:2]([F:1])([F:23])[F:24])(=[O:11])=[O:10])[CH2:13][CH2:14]3)[C:19]2=[O:20])=[CH:31][CH:30]=1)[OH:28]

Participants

3

Reactant 2

HCID 594408652,2,2-Trifluoro-1-(4-iodophenyl)ethanolHCID 595779268-(2-Trifluoromethyl-benzenesulfonyl)-2,8-diaza-spiro[4.5]decan-1-one

Product 1

HCID 595779442-(4-(2,2,2-Trifluoro-1-hydroxyethyl)phenyl)-8-(2-(trifluoromethyl)phenylsulfonyl)-2,8-diazaspiro[4.5]decan-1-one

Procedure

This material was prepared in analogy to example 162 B) from 8-(2-trifluoromethyl-benzenesulfonyl)-2,8-diaza-spiro[4.5]decan-1-one and 2,2,2-trifluoro-1-(4-iodo-phenyl)-ethanol. White solid. MS (ESI): 537.12 MH+).

Sources & evidence

ORD record
ord-69ed9138c12d43f49ad46f9ba35cc482
Source dataset
uspto-grants-2012_12
Patent number
US08329904B2

Reaction notes

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