2,2,2-Trifluoro-1-(4-iodophenyl)ethanol → 8-(Cyclopropylsulfonyl)-2-(4-(2,2,2-trifluoro-1-hydroxyethyl)phenyl)-2,8-diazaspiro[4.5]decan-1-one

HRID 2194151Notes

Reaction equation

HRID 2194151 reaction equation
[CH:1]1([S:4]([N:7]2[CH2:17][CH2:16][C:10]3([C:14](=[O:15])[NH:13][CH2:12][CH2:11]3)[CH2:9][CH2:8]2)(=[O:6])=[O:5])[CH2:3][CH2:2]1.[F:18][C:19]([F:30])([F:29])[CH:20]([C:22]1[CH:27]=[CH:26][C:25](I)=[CH:24][CH:23]=1)[OH:21]>>[CH:1]1([S:4]([N:7]2[CH2:17][CH2:16][C:10]3([C:14](=[O:15])[N:13]([C:25]4[CH:26]=[CH:27][C:22]([CH:20]([OH:21])[C:19]([F:29])([F:30])[F:18])=[CH:23][CH:24]=4)[CH2:12][CH2:11]3)[CH2:9][CH2:8]2)(=[O:5])=[O:6])[CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 594408652,2,2-Trifluoro-1-(4-iodophenyl)ethanolHCID 595779488-(Cyclopropylsulfonyl)-2,8-diazaspiro[4.5]decan-1-one

Product 1

HCID 595779698-(Cyclopropylsulfonyl)-2-(4-(2,2,2-trifluoro-1-hydroxyethyl)phenyl)-2,8-diazaspiro[4.5]decan-1-one

Procedure

This material was prepared In analogy to example 162 step B) from 8-(cyclopropylsulfonyl)-2,8-diazaspiro[4.5]decan-1-one and 2,2,2-trifluoro-1-(4-iodo-phenyl)-ethanol. White solid. MS (ESI): 433.14 MH+).

Sources & evidence

ORD record
ord-5edd8aebb23749858f83ed8af551d6b1
Source dataset
uspto-grants-2012_12
Patent number
US08329904B2

Reaction notes

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