Cyclopropylamine → 8-(2-Cyclopropylamino-pyridine-3-sulfonyl)-2-(4-trifluoromethoxy-phenyl)-2,8-diaza-spiro[4.5]decan-1-one

HRID 2194172Notes

Reaction equation

HRID 2194172 reaction equation
Cl[C:2]1[C:7]([S:8]([N:11]2[CH2:32][CH2:31][C:14]3([C:18](=[O:19])[N:17]([C:20]4[CH:25]=[CH:24][C:23]([O:26][C:27]([F:30])([F:29])[F:28])=[CH:22][CH:21]=4)[CH2:16][CH2:15]3)[CH2:13][CH2:12]2)(=[O:10])=[O:9])=[CH:6][CH:5]=[CH:4][N:3]=1.[CH:33]1([NH2:36])[CH2:35][CH2:34]1>>[CH:33]1([NH:36][C:2]2[C:7]([S:8]([N:11]3[CH2:12][CH2:13][C:14]4([C:18](=[O:19])[N:17]([C:20]5[CH:25]=[CH:24][C:23]([O:26][C:27]([F:28])([F:30])[F:29])=[CH:22][CH:21]=5)[CH2:16][CH2:15]4)[CH2:31][CH2:32]3)(=[O:10])=[O:9])=[CH:6][CH:5]=[CH:4][N:3]=2)[CH2:35][CH2:34]1

Participants

3

Reactant 2

HCID 69828CyclopropylamineHCID 595779608-(2-Chloro-pyridine-3-sulfonyl)-2-(4-trifluoromethoxy-phenyl)-2,8-diaza-spiro[4.5]decan-1-one

Product 1

HCID 595778878-(2-Cyclopropylamino-pyridine-3-sulfonyl)-2-(4-trifluoromethoxy-phenyl)-2,8-diaza-spiro[4.5]decan-1-one

Procedure

The title compound was prepared in analogy to example 189 from 8-(2-chloro-pyridine-3-sulfonyl)-2-(4-trifluoromethoxy-phenyl)-2,8-diaza-spiro[4.5]decan-1-one (described in example 188) and cyclopropyl amine. Light yellow oil. MS (ESI): 511.2 (MH+).

Sources & evidence

ORD record
ord-090cb565f4994f4ead5945a5c72a5f26
Source dataset
uspto-grants-2012_12
Patent number
US08329904B2

Reaction notes

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