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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2194172Generated: October 31, 2026

Cyclopropylamine → 8-(2-Cyclopropylamino-pyridine-3-sulfonyl)-2-(4-trifluoromethoxy-phenyl)-2,8-diaza-spiro[4.5]decan-1-one

https://huagongshe.com/reaction/2194172

Reaction equation

Participants

RoleNameHCIDCharge
ReactantCyclopropylamineHCID 69828—
Reactant8-(2-Chloro-pyridine-3-sulfonyl)-2-(4-trifluoromethoxy-phenyl)-2,8-diaza-spiro[4.5]decan-1-oneHCID 59577960—
Product8-(2-Cyclopropylamino-pyridine-3-sulfonyl)-2-(4-trifluoromethoxy-phenyl)-2,8-diaza-spiro[4.5]decan-1-oneHCID 59577887—

Reaction Steps

The title compound was prepared in analogy to example 189 from 8-(2-chloro-pyridine-3-sulfonyl)-2-(4-trifluoromethoxy-phenyl)-2,8-diaza-spiro[4.5]decan-1-one (described in example 188) and cyclopropyl amine. Light yellow oil. MS (ESI): 511.2 (MH+).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08329904B2
Source datasetuspto-grants-2012_12
ORD IDord-090cb565f4994f4ead5945a5c72a5f26
Source noteuspto-grants-2012_12