Methylamine → HCID 59577899, compound

HRID 2194184Notes

Reaction equation

Cl[C:2]1[C:7]([S:8]([N:11]2[CH2:33][CH2:32][C:14]3([C:18](=[O:19])[N:17]([C:20]4[CH:25]=[CH:24][C:23]([O:26][CH2:27][C:28]([F:31])([F:30])[F:29])=[CH:22][CH:21]=4)[CH2:16][CH2:15]3)[CH2:13][CH2:12]2)(=[O:10])=[O:9])=[CH:6][CH:5]=[CH:4][N:3]=1.[CH3:34][NH2:35]>>[CH3:34][NH:35][C:2]1[C:7]([S:8]([N:11]2[CH2:12][CH2:13][C:14]3([C:18](=[O:19])[N:17]([C:20]4[CH:21]=[CH:22][C:23]([O:26][CH2:27][C:28]([F:30])([F:29])[F:31])=[CH:24][CH:25]=4)[CH2:16][CH2:15]3)[CH2:32][CH2:33]2)(=[O:10])=[O:9])=[CH:6][CH:5]=[CH:4][N:3]=1

Participants

Reactant 2

HCID 6329Methylamine

HCID 59578053HCID 59578053, compound

Product 1

HCID 59577899HCID 59577899, compound

Procedure

The title compound was prepared in analogy to example 189 from 8-(2-Chloro-pyridine-3-sulfonyl)-2-[4-(2,2,2-trifluoro-ethoxy)-phenyl]-2,8-diaza-spiro[4.5]decan-1-one (described in example 206) and methyl amine. Off-white solid. MS (ESI): 499.3 (MH+).

Sources & evidence

ORD record: ord-775113670609425985363fe2592cf0a7
Source dataset: uspto-grants-2012_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08329904B2

Reaction notes

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