Methyl iodide → 8-(1-Methoxy-cyclopentylmethanesulfonyl)-2-(4-trifluoromethoxy-phenyl)-2,8-diaza-spiro[4.5]decan-1-one

HRID 2194189Notes

Reaction equation

HRID 2194189 reaction equation
[OH:1][C:2]1([CH2:7][S:8]([N:11]2[CH2:32][CH2:31][C:14]3([C:18](=[O:19])[N:17]([C:20]4[CH:25]=[CH:24][C:23]([O:26][C:27]([F:30])([F:29])[F:28])=[CH:22][CH:21]=4)[CH2:16][CH2:15]3)[CH2:13][CH2:12]2)(=[O:10])=[O:9])[CH2:6][CH2:5][CH2:4][CH2:3]1.[CH3:33]I>>[CH3:33][O:1][C:2]1([CH2:7][S:8]([N:11]2[CH2:12][CH2:13][C:14]3([C:18](=[O:19])[N:17]([C:20]4[CH:21]=[CH:22][C:23]([O:26][C:27]([F:28])([F:29])[F:30])=[CH:24][CH:25]=4)[CH2:16][CH2:15]3)[CH2:31][CH2:32]2)(=[O:10])=[O:9])[CH2:3][CH2:4][CH2:5][CH2:6]1

Participants

3

Reactant 2

HCID 6328Methyl iodideHCID 595780138-(1-Hydroxy-cyclopentylmethanesulfonyl)-2-(4-trifluoromethoxy-phenyl)-2,8-diaza-spiro[4.5]decan-1-one

Product 1

HCID 595780598-(1-Methoxy-cyclopentylmethanesulfonyl)-2-(4-trifluoromethoxy-phenyl)-2,8-diaza-spiro[4.5]decan-1-one

Procedure

The title compound was prepared in analogy to example 209 from 8-(1-hydroxy-cyclopentylmethanesulfonyl)-2-(4-trifluoromethoxy-phenyl)-2,8-diaza-spiro[4.5]decan-1-one (described in example 210) and methyl iodide. Off-white solid. MS (ESI): 491.2 (MH+).

Sources & evidence

ORD record
ord-a94ae858445043579d77e561ddfd2234
Source dataset
uspto-grants-2012_12
Patent number
US08329904B2

Reaction notes

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