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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2194189Generated: October 31, 2026

Methyl iodide → 8-(1-Methoxy-cyclopentylmethanesulfonyl)-2-(4-trifluoromethoxy-phenyl)-2,8-diaza-spiro[4.5]decan-1-one

https://huagongshe.com/reaction/2194189

Reaction equation

Participants

RoleNameHCIDCharge
ReactantMethyl iodideHCID 6328—
Reactant8-(1-Hydroxy-cyclopentylmethanesulfonyl)-2-(4-trifluoromethoxy-phenyl)-2,8-diaza-spiro[4.5]decan-1-oneHCID 59578013—
Product8-(1-Methoxy-cyclopentylmethanesulfonyl)-2-(4-trifluoromethoxy-phenyl)-2,8-diaza-spiro[4.5]decan-1-oneHCID 59578059—

Reaction Steps

The title compound was prepared in analogy to example 209 from 8-(1-hydroxy-cyclopentylmethanesulfonyl)-2-(4-trifluoromethoxy-phenyl)-2,8-diaza-spiro[4.5]decan-1-one (described in example 210) and methyl iodide. Off-white solid. MS (ESI): 491.2 (MH+).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08329904B2
Source datasetuspto-grants-2012_12
ORD IDord-a94ae858445043579d77e561ddfd2234
Source noteuspto-grants-2012_12