3-Hydroxy-3-methylpentanoic acid → HCID 59577958, compound

HRID 2194193Notes

Reaction equation

HRID 2194193 reaction equation
CN(C(ON1N=NC2C=CC=CC1=2)=[N+](C)C)C.[B-](F)(F)(F)F.C(O)(=O)C.[F:27][C:28]([F:48])([F:47])[O:29][C:30]1[CH:35]=[CH:34][C:33]([N:36]2[CH2:40][CH2:39][C:38]3([CH2:45][CH2:44][NH:43][CH2:42][CH2:41]3)[C:37]2=[O:46])=[CH:32][CH:31]=1.[OH:49][C:50]([CH3:57])([CH2:55][CH3:56])[CH2:51][C:52](O)=[O:53]>>[OH:49][C:50]([CH3:57])([CH2:55][CH3:56])[CH2:51][C:52]([N:43]1[CH2:42][CH2:41][C:38]2([C:37](=[O:46])[N:36]([C:33]3[CH:34]=[CH:35][C:30]([O:29][C:28]([F:27])([F:47])[F:48])=[CH:31][CH:32]=3)[CH2:40][CH2:39]2)[CH2:45][CH2:44]1)=[O:53]

Participants

4

Reactant 3

HCID 5382883-Hydroxy-3-methylpentanoic acidHCID 2733207O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborateHCID 667873332-(4-Trifluoromethoxy-phenyl)-2,8-diaza-spiro[4.5]decan-1-one acetic acid salt

Product 1

HCID 59577958HCID 59577958, compound

Procedure

The title compound was prepared in analogy to example 13 step A (using TBTU instead of BOP as the coupling reagent) from 2-(4-trifluoromethoxy-phenyl)-2,8-diaza-spiro[4.5]decan-1-one acetic acid salt (described in example 180 step C) and 3-hydroxy-3-methyl-pentanoic acid. Light brown oil. MS (ESI): 429.2 (MH+).

Sources & evidence

ORD record
ord-b7c2043098a546c08a5791def872e36f
Source dataset
uspto-grants-2012_12
Patent number
US08329904B2

Reaction notes

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