5-Bromo-2,2-difluoro-1,3-benzodioxole → HCID 59578084, compound

HRID 2194206Notes

Reaction equation

HRID 2194206 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[S:8]([N:11]1[CH2:21][CH2:20][C:14]2([C:18](=[O:19])[NH:17][CH2:16][CH2:15]2)[CH2:13][CH2:12]1)(=[O:10])=[O:9].Br[C:23]1[CH:33]=[CH:32][C:26]2[O:27][C:28]([F:31])([F:30])[O:29][C:25]=2[CH:24]=1>>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[S:8]([N:11]1[CH2:21][CH2:20][C:14]2([C:18](=[O:19])[N:17]([C:33]3[CH:23]=[CH:24][C:25]4[O:29][C:28]([F:30])([F:31])[O:27][C:26]=4[CH:32]=3)[CH2:16][CH2:15]2)[CH2:13][CH2:12]1)(=[O:9])=[O:10]

Participants

3

Reactant 2

HCID 27362715-Bromo-2,2-difluoro-1,3-benzodioxoleHCID 595779948-(2-Chloro-benzenesulfonyl)-2,8-diaza-spiro[4.5]decan-1-one

Product 1

HCID 59578084HCID 59578084, compound

Procedure

The title compound was prepared in analogy to example 148 step F) from 8-(2-chloro-benzenesulfonyl)-2,8-diaza-spiro[4.5]decan-1-one (described in example 148 step E or example 179 step A for an alternative synthesis) and 5-bromo-2,2-difluoro-benzo[1,3]dioxole. Off-white solid. MS (ESI): 485.1 (MH+).

Sources & evidence

ORD record
ord-722016cb51fa45088a682831a6627cb5
Source dataset
uspto-grants-2012_12
Patent number
US08329904B2

Reaction notes

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