Diphosgene → HCID 59578049, compound

HRID 2194240Notes

Reaction equation

HRID 2194240 reaction equation
[CH2:1]([C:3]1[CH:8]=[CH:7][C:6]([N:9]2[CH2:13][CH2:12][C:11]3([CH2:18][CH2:17][NH:16][CH2:15][CH2:14]3)[C:10]2=[O:19])=[CH:5][CH:4]=1)[CH3:2].O=C(Cl)[O:22][C:23](Cl)(Cl)Cl.[F:28][C:29]1[CH:36]=[CH:35][C:32]([CH2:33][NH2:34])=[CH:31][CH:30]=1>>[F:28][C:29]1[CH:36]=[CH:35][C:32]([CH2:33][NH:34][C:23]([N:16]2[CH2:17][CH2:18][C:11]3([C:10](=[O:19])[N:9]([C:6]4[CH:5]=[CH:4][C:3]([CH2:1][CH3:2])=[CH:8][CH:7]=4)[CH2:13][CH2:12]3)[CH2:14][CH2:15]2)=[O:22])=[CH:31][CH:30]=1

Participants

4

Reactant 3

HCID 10426DiphosgeneHCID 673264-FluorobenzylamineHCID 58287273HCID 58287273, compound

Product 1

HCID 59578049HCID 59578049, compound

Procedure

This material was prepared in analogy to example 251 step B) from 2-(4-Ethyl-phenyl)-2,8-diaza-spiro[4.5]decan-1-one, diphosgene and 4-Fluoro-benzylamine. MS (ESI): 410.4 (MH+).

Sources & evidence

ORD record
ord-6bf2f933a4074b32b44c3945a97fdd0d
Source dataset
uspto-grants-2012_12
Patent number
US08329904B2

Reaction notes

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