Diphosgene → HCID 59577876, compound

HRID 2194263Notes

Reaction equation

HRID 2194263 reaction equation
[F:1][C:2]([F:22])([F:21])[O:3][C:4]1[CH:9]=[CH:8][C:7]([N:10]2[CH2:14][CH2:13][C:12]3([CH2:19][CH2:18][NH:17][CH2:16][CH2:15]3)[C:11]2=[O:20])=[CH:6][CH:5]=1.O=C(Cl)[O:25][C:26](Cl)(Cl)Cl.[CH2:31]([NH:33][CH2:34][CH2:35][C:36]1[CH:41]=[CH:40][CH:39]=[CH:38][N:37]=1)[CH3:32]>>[CH2:31]([N:33]([CH2:34][CH2:35][C:36]1[CH:41]=[CH:40][CH:39]=[CH:38][N:37]=1)[C:26]([N:17]1[CH2:16][CH2:15][C:12]2([C:11](=[O:20])[N:10]([C:7]3[CH:8]=[CH:9][C:4]([O:3][C:2]([F:1])([F:21])[F:22])=[CH:5][CH:6]=3)[CH2:14][CH2:13]2)[CH2:19][CH2:18]1)=[O:25])[CH3:32]

Participants

4

Reactant 3

HCID 10426DiphosgeneHCID 80553N-Ethylpyridine-2-ethylamineHCID 667427592-(4-(Trifluoromethoxy)phenyl)-2,8-diazaspiro[4.5]decan-1-one

Product 1

HCID 59577876HCID 59577876, compound

Procedure

This material was prepared in analogy to example 251 step B) from 2-(4-trifluoromethoxy-phenyl)-2,8-diaza-spiro[4.5]decan-1-one, diphosgene and ethyl-(2-pyridin-2-yl-ethyl)-amine. MS (ESI): 491.4 (MH+).

Sources & evidence

ORD record
ord-5b1e317ace5b4d508739214fd561d6e4
Source dataset
uspto-grants-2012_12
Patent number
US08329904B2

Reaction notes

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