反应详情

温度

50 °C

A mixture of 74 mg (0.18 mmol) 1-Oxo-2-(4-trifluoromethoxy-phenyl)-2,8-diaza-spiro[4.5]decane-8-sulfonyl chloride, 73 mg (0.72 mmol) NEt3 and 14.8 mg (0.252 mmol) isopropylamine in 2 mL CH2Cl2 was stirred for 16 h at 50° C. The mixture was evaporated to dryness and the residue was subjected to purification by preparative HPLC on reversed phase eluting with a gradient formed from acetonitrile, water and formic acid. The product containing fractions were evaporated to yield 12.5 mg (16%) of the title compound. MS (ESI): 436.4 (MH+).

1. customThe mixture was evaporated to dryness
2. customthe residue was subjected to purification by preparative HPLC on reversed phase
3. washeluting with a gradient
4. customformed from acetonitrile, water and formic acid
5. additionThe product containing fractions
6. customwere evaporated