Diphosgene → HCID 59578017, compound

HRID 2194286Notes

Reaction equation

HRID 2194286 reaction equation
[F:1][C:2]([F:22])([F:21])[O:3][C:4]1[CH:9]=[CH:8][C:7]([N:10]2[CH2:14][CH2:13][C:12]3([CH2:19][CH2:18][NH:17][CH2:16][CH2:15]3)[C:11]2=[O:20])=[CH:6][CH:5]=1.[O:23]=[C:24](Cl)OC(Cl)(Cl)Cl.[Cl:31][C:32]1[CH:37]=[CH:36][C:35]([NH:38][CH2:39][CH3:40])=[CH:34][CH:33]=1>>[Cl:31][C:32]1[CH:37]=[CH:36][C:35]([N:38]([CH2:39][CH3:40])[C:24]([N:17]2[CH2:16][CH2:15][C:12]3([C:11](=[O:20])[N:10]([C:7]4[CH:8]=[CH:9][C:4]([O:3][C:2]([F:1])([F:21])[F:22])=[CH:5][CH:6]=4)[CH2:14][CH2:13]3)[CH2:19][CH2:18]2)=[O:23])=[CH:34][CH:33]=1

Participants

4

Reactant 3

HCID 10426DiphosgeneHCID 5878414-chloro-N-ethylanilineHCID 667427592-(4-(Trifluoromethoxy)phenyl)-2,8-diazaspiro[4.5]decan-1-one

Product 1

HCID 59578017HCID 59578017, compound

Conditions

Temperature
80 °C

Procedure

This material was prepared in analogy to example 251 step B) from 2-(4-trifluoromethoxy-phenyl)-2,8-diaza-spiro[4.5]decan-1-one, diphosgene and (4-chloro-phenyl)-ethyl-amine. The reaction mixture was stirred for 1 h at room temperature, 2 h at 50° C. and 1 h at 80° C. before subjecting to work-up and purification. MS (ESI): 496.4 (MH+).

Workup

  1. custompurification

Sources & evidence

ORD record
ord-bf4706eeeec649769620a0bb8f9e18cc
Source dataset
uspto-grants-2012_12
Patent number
US08329904B2

Reaction notes

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