Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Diphosgene | HCID 10426 | — |
| Reactant | N-Ethyl-4-(trifluoromethoxy)aniline | HCID 2777281 | — |
| Reactant | 2-(4-(Trifluoromethoxy)phenyl)-2,8-diazaspiro[4.5]decan-1-one | HCID 66742759 | — |
| Product | HCID 59577990 | HCID 59577990 | — |
Reaction Steps
This material was prepared in analogy to example 251 step B) from 2-(4-trifluoromethoxy-phenyl)-2,8-diaza-spiro[4.5]decan-1-one, diphosgene and ethyl-(4-trifluoromethoxy-phenyl)-amine. The reaction mixture was stirred for 1 h at room temperature, 2 h at 50° C. and 1 h at 80° C. before subjecting to work-up and purification. MS (ESI): 546.5 (MH+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08329904B2 |
|---|
| Source dataset | uspto-grants-2012_12 |
|---|
| ORD ID | ord-9fdad202779d4c1dbe5f27dfbf714e37 |
|---|
| Source note | uspto-grants-2012_12 |
|---|
