Diphosgene → HCID 59577990, compound

HRID 2194288Notes

Reaction equation

HRID 2194288 reaction equation
[F:1][C:2]([F:22])([F:21])[O:3][C:4]1[CH:9]=[CH:8][C:7]([N:10]2[CH2:14][CH2:13][C:12]3([CH2:19][CH2:18][NH:17][CH2:16][CH2:15]3)[C:11]2=[O:20])=[CH:6][CH:5]=1.[O:23]=[C:24](Cl)OC(Cl)(Cl)Cl.[CH2:31]([NH:33][C:34]1[CH:39]=[CH:38][C:37]([O:40][C:41]([F:44])([F:43])[F:42])=[CH:36][CH:35]=1)[CH3:32]>>[CH2:31]([N:33]([C:34]1[CH:35]=[CH:36][C:37]([O:40][C:41]([F:42])([F:43])[F:44])=[CH:38][CH:39]=1)[C:24]([N:17]1[CH2:16][CH2:15][C:12]2([C:11](=[O:20])[N:10]([C:7]3[CH:8]=[CH:9][C:4]([O:3][C:2]([F:1])([F:21])[F:22])=[CH:5][CH:6]=3)[CH2:14][CH2:13]2)[CH2:19][CH2:18]1)=[O:23])[CH3:32]

Participants

4

Reactant 3

HCID 10426DiphosgeneHCID 2777281N-Ethyl-4-(trifluoromethoxy)anilineHCID 667427592-(4-(Trifluoromethoxy)phenyl)-2,8-diazaspiro[4.5]decan-1-one

Product 1

HCID 59577990HCID 59577990, compound

Conditions

Temperature
80 °C

Procedure

This material was prepared in analogy to example 251 step B) from 2-(4-trifluoromethoxy-phenyl)-2,8-diaza-spiro[4.5]decan-1-one, diphosgene and ethyl-(4-trifluoromethoxy-phenyl)-amine. The reaction mixture was stirred for 1 h at room temperature, 2 h at 50° C. and 1 h at 80° C. before subjecting to work-up and purification. MS (ESI): 546.5 (MH+).

Workup

  1. custompurification

Sources & evidence

ORD record
ord-9fdad202779d4c1dbe5f27dfbf714e37
Source dataset
uspto-grants-2012_12
Patent number
US08329904B2

Reaction notes

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