Diphosgene → HCID 59577946, compound

HRID 2194291Notes

Reaction equation

HRID 2194291 reaction equation
[CH:1]1([C:4]2[CH:9]=[CH:8][C:7]([N:10]3[CH2:14][CH2:13][C:12]4([CH2:19][CH2:18][NH:17][CH2:16][CH2:15]4)[C:11]3=[O:20])=[CH:6][CH:5]=2)[CH2:3][CH2:2]1.O=C(Cl)[O:23][C:24](Cl)(Cl)Cl.[CH2:29]([NH:33][CH3:34])[CH:30]([CH3:32])[CH3:31]>>[CH2:29]([N:33]([CH3:34])[C:24]([N:17]1[CH2:18][CH2:19][C:12]2([C:11](=[O:20])[N:10]([C:7]3[CH:8]=[CH:9][C:4]([CH:1]4[CH2:3][CH2:2]4)=[CH:5][CH:6]=3)[CH2:14][CH2:13]2)[CH2:15][CH2:16]1)=[O:23])[CH:30]([CH3:32])[CH3:31]

Participants

4

Reactant 3

HCID 10426DiphosgeneHCID 12249N-MethylisobutylamineHCID 582872772-(4-Cyclopropyl-phenyl)-2,8-diaza-spiro[4.5]decan-1-one

Product 1

HCID 59577946HCID 59577946, compound

Procedure

This material was prepared in analogy to example 251 step B) from 2-(4-Cyclopropyl-phenyl)-2,8-diaza-spiro[4.5]decan-1-one, diphosgene and isobutyl-methyl-amine. MS (ESI): 384.3 (MH+).

Sources & evidence

ORD record
ord-e0bcbd8c38bb41489c0dad0d30b23601
Source dataset
uspto-grants-2012_12
Patent number
US08329904B2

Reaction notes

Loading…